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Magnesium: The Fact That Can Kill You

3/26/2018

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Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

Magnesium can be the one thing that can save someone from an instantaneous deadly heart attack. In fact, it could be the answer for an out of control arrhythmia.

Going back as far as 1990 
the Journal of the American Medical Association reported that well over half of hospitalized patients were seriously low in magnesium.

​Unfortunately, the reporting of these findings were not by the physicians in the hospital but by respected scientists and researchers doing the study.

The sad truth of it all is over 90% of these physicians 
never ordered any magnesium test.
 
Those having the lowest levels of magnesium had the highest risk of dying from a heart attack or a deadly arrhythmia while in the hospital.
 
Government studies prove the average diet provides less than a third of the magnesium you need in a day and its deficiency is a major cause of sudden death with no other obvious medical problems.
 
Even diabetics are at risk of developing deadly complications due to a deficiency in magnesium. A respected medical study reported that 77% of diabetics were deficient in magnesium.
 
Here is a fact that everyone MUST remember.
 
Do not accept that your magnesium levels are normal if your doctor has ordered the inferior "serum" magnesium test.
 
Here is the kicker!
 
If your serum magnesium levels are shown to be high your doctor may assume everything is fine and lead you to believe there is nothing to worry about.
 
This is 100% incorrect and could be deadly!
 
Why you may ask?
 
Because as the magnesium inside the heart cell goes down, the body tries to compensate. So the serum magnesium actually goes up!
 
The serum magnesium can actually be high or even too high, when at that same time your RBC magnesium (inside the heart cells) is so low you could have an instantaneous fatal heart attack.

--
This is an extremely important fact for you to know: the serum magnesium (called simply "magnesium" when you see your lab test) can actually be high or even too high, when at that same time your RBC magnesium (inside the heart cells) is so low you could have an instantaneous fatal heart attack.
 
Here is something even more frightening.
 
When your "intracellular" magnesium levels are low and you suffer a heart attack or an arrhythmia not even the easy access of a defibrillator or paddles can activate the heart back to life.
 
So the point is quite clear... never never never buy into "everything is just fine" if your doctor has ordered the worthless serum magnesium.
 
Unfortunately, the serum magnesium gives the unknowledgeable physician a sense of security when in fact they are clueless to the great harm they may be instilling on their patients.
 
The result of this lack of knowledge could be the patient dies or has a life threatening arrhythmia all because the wrong magnesium blood test was ordered.
 
If you want to be certain your levels of magnesium are well within the normal range, insist that your doctor orders the most accurate magnesium test and that is the red blood cell (RBC) essential mineral test. The RBC test can be ordered from www.gdx.net or www.doctorsdata.com




​
References:
  • Sales CH, et al, Magnesium and diabetes mellitus: their relations, Clin Nutr 25; 4:554-62, 2006
  • Sales CH, et al, Influence of magnesium status and magnesium intake on the blood glucose control, in patients with type II diabetes, Clin Nutr, 2011
  • Nielsen FH, et al., Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance and increases serum cholesterol in postmenopausal women, J Am Coll Nutr 26; 2:121-32, 2007
  • Whang R, et al, Frequency of hypomagnesemia and hypermagnesemia, requested versus routine, J Am Med Assoc, 2634:3063-4, 1990

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. 

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Alzheimer's or Brain Diabetes?

3/19/2018

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By: Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

A growing body of research suggests there's a powerful connection between your diet and your risk of Alzheimer's disease via similar pathways that cause type 2 diabetes.
Back in 2005, a published medical paper introduced a new disease tentatively dubbed "type 3 diabetes".

The researchers learned that, in addition to the pancreas, your brain also produces insulin.
They discovered that without the insulin your brain cells will die.
A drop in insulin production in your brain may contribute to the degeneration of your brain cells, and studies have found that people with lower levels of insulin and insulin receptors in their brain often have Alzheimer's disease.
Studies since 2005 have continually documented that insulin has a much greater role in the brain than previously expected.
Insulin is directly responsible for neuron glucose-uptake, and the regulation of neurotransmitters like acetylcholine, which are crucial for memory and learning.
Scientists have come to understand that cognition is impaired when insulin levels are reduced.
The clinical research has made it quite clear that the same pathological process that leads to insulin resistance and type 2 diabetes may also hold true for your brain.
The take away from these studies make a strong point that the over-consumption of sugars and "grains" which are also detrimental to the the development of diabetes may also result in Type 3 Diabetes (brain diabetes).
When the brain becomes overwhelmed by the consistently high levels of glucose, the insulin signaling will eventually become blunted or desensitized. This will lead to impairments in your thinking and memory abilities, eventually causing permanent brain damage.
Healthcare clinicians trained in functional medicine have the training and knowledge to investigate what is at the root of the pathological process that leads to Type 2 diabetes and the new diagnosis of Type 3 diabetes.
The one size fits all approach of prescriptive medications for diabetes, although of some value, will not shut down the physiological cascade of the consequences of poor sugar/insulin control. 
To find a healthcare professional certified in functional medicine, go to www.FunctionalMedicineDoctors.com.These are clinicians who have been trained at Functional Medicine University (www.FunctionalMedicineUniversity.com)

Reference:
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis. 2005 Feb;7(1):63-80.
de la Monte, Wands.Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed, J Diabetes Sci Technol. 2008 Nov; 2(6): 1101–1113.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Visit www.FunctionalMedicineUniversity.com for more information on our training in functional medicine.
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Risk of Breast Cancer? Do you know your estrogen metabolites?

3/12/2018

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Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

Estrogen alone is not the issue when it comes to increasing the risk of breast cancer. The real issue is how is your estrogen being metabolized. You want to have your doctor order a test that evaluates the estrogen metabolites. **I recommend the Dutch Test (https://dutchtest.com)
​

The liver converts estrogens into estrogen metabolites. Three of estrogen's metabolites, the breakdown products of this hormone, are 2-hydroxyestrone, 4-hydroxyestrone, and 16-alpha-hydroxyestrone.




Since the 1980s, 2-hydroxyestrone has been considered a "good" or chemoprotective form of estrogen, while 16-alpha-hydroxyestrone has been associated with the development of cancer. It can fuel the growth and division of hormone-dependent and other cancer cells more than the 2-hydroxyestrones can. The 2-hydroxyestrones, in contrast, have almost no estrogenic effect. Prevailing evidence has shown that the ratio of 2-hydroxyestrone to 16-alpha-hydroxyestrone is relevant as a risk factor for estrogen-sensitive cancers, including breast and cervical cancers. Simply put, when it comes to estrogen metabolites, you want more 2s than 16s. And guess what can help the body do that? Cruciferous vegetables.

Two components in cruciferous vegetables are indole-3-carbinol (I3C) and diindolylmethane (DIM). Studies have found that these compounds can inhibit the formation of the "bad" 16-alpha-hydroxyestrone estrogen metabolite. One study found that DIM had the ability to decrease its production by 50 percent while increasing production of the "good" 2-hydroxyestrone metabolite by 75 percent.
I3C is found in a number of cruciferous vegetables, including broccoli, brussels sprouts, cabbage, cauliflower, collard greens, kale, kohlrabi, mustard greens, radish, rutabaga, and turnip. The highest concentrations are found in garden cress (different from watercress) and mustard greens.

References:
Winters Nasha, Kelley Jess, The Metabolic Approach to Cancer, Chelsea Green Publishing, 2017
Michelle Whirl-Carrillo, Ellen M. McDonagh, J. M. Hebert, H Chun Gong, K. Sangkuhl, C. F. Thorn, Russ B. Altman, and T. E. Klein, "Pharmacogenomics Knowledge for Personalized Medicine," Clinical Pharmacology and Therapeutics 92, no. 4 (October 2012): 414-17
Heather Greenlee, Yu Chen, Geoffrey C. Kabat, Qiao Wang, Muhammad G. Kibriya, Irina Gurvich, Daniel W Sepkovic, et al., "Variants in Estrogen Metabolism and Biosynthesis Genes and Urinary Estrogen Metabolites in Women with a Family History of Breast Cancer," Breast Cancer Research and Treatment 102, no. 1 (March 2007): 111-17
To find a healthcare professional certified in functional medicine, go to www.FunctionalMedicineDoctors.com. These are clinicians who have been trained at Functional Medicine University (www.FunctionalMedicineUniversity.com)


The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Visit www.FunctionalMedicineUniversity.com for more information on our training in functional medicine. 

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This amazing food has shown powerful immune-boosting and anticancer activity--including blocking the formation of tumors.

3/5/2018

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Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.Medicinal Mushrooms
One food source that has been thoroughly researched in its role in immune stimulation and cancer are Medicinal Mushrooms. This amazing food has the ability to complement chemotherapy and radiation therapy by countering several of the side effects of these modalities, including nausea, bone marrow suppression, anemia, and lowered resistance. The following mushrooms have shown powerful immune-boosting and anticancer activity—including blocking the formation of tumors. These mushrooms contain polysaccharides, substances that increase immune defense by enhancing the function of macrophages and natural killer (NK) cells.
Turkey Tail
A seven-year clinical study funded by the National Institutes of Health and jointly conducted by the University of Minnesota and Bastyr University in Seattle found that freeze-dried turkey tail mushroom had a dramatic impact in boosting immune function for women with stages I, II, and III breast cancer and also contributed to tumor shrinkage."
Maitake
This mushroom, also 'known as hen of the wood' has been found to inhibit tumor growth in human clinical trials. It has also been found to increase the production of interleukins, neutrophils, T cells, and macrophages while decreasing side effects of chemotherapy.
Shiitake
A 2015 University of Florida study showed increased immunity in people who ate a cooked shiitake mushroom every day for four weeks." By comparing blood tests obtained both before and after the experiment, researchers saw better functioning immune cells and reductions in inflammatory proteins.
Reisshi  ("Mushroom of Immortality")
Reisshi  mushrooms contain beta glucans, a type of polysaccharide that has demonstrated antitumor and immunostimulating activity. Recent findings indicate that reishi mushrooms may increase NK cell cytotoxicity against cancer cell lines. They may also protect against radiation damage.
Lion's Mane
Lion's mane mushrooms have been demonstrated to stimulate NK and macrophage activity and also to inhibit angiogenesis (the development of new blood vessels), contributing to reduction of tumor size. It was also discovered that when the mushroom was combined with the chemotherapy drug doxorubicin, an otherwise drug-resistant human liver cancer became treatable.
Cordyceps
Evidence shows that cordyceps is an immune modulator with potentiating and suppressive effects on both innate and adaptive immunity. It enhances the activity of NK cells and has been found to initiate T cell responses against microbial pathogens and tumors."
Conclusion: As you can see from the above, Medicinal Mushrooms should be included in everyone's diet to enhance immune function and has promise in the management of cancer.


References:
Winters Nasha, Kelley Jess, The Metabolic Approach to Cancer, Chelsea Green Publishing, 2017
Seema Patel, Arun Goyal, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech. 2012 Mar; 2(1): 1–15.
Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ., Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.
Alena G. Guggenheim, Kirsten M. Wright, and Heather L. Zwickey, "Immune Modulation from Five Major Mushrooms: Application to Integrative Oncology" Integrative Medicine 13, no. 1 (February 2014): 32-44
Xiaoshuang Dai, Joy M. Stanilka, Cheryl A. Rowe, Elizabethe A. Esteves, Carmelo Nieves, Samuel J. Spaiser, Mary C. Christman, Bobbi Langlcamp-Henken, and Susan S. Percival, "Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults," Journal of the American College of Nutrition 34, no. 6 (2015): 478-87,
Patel and Goyal, "Recent Developments in Mushrooms as Anti-Cancer Therapeutics: A Review."
Bao-qin Lin and Shao-ping Li, "Cordyceps as an Herbal Drug," chap. 5 in Benzie and Wachtel-Galor, eds., Herbal Medicine: Biomolecular and Clinical Aspects.
To find a healthcare professional certified in functional medicine, go to www.FunctionalMedicineDoctors.com. These are clinicians who have been trained at Functional Medicine University (www.FunctionalMedicineUniversity.com)


The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
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    • Understanding Hormones Highs and Lows
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    • Estrogen Dominance
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